Sustained nonoxidative glucose utilization and depletion of glycogen in reperfused canine myocardium
نویسندگان
چکیده
منابع مشابه
Quantitative assessment of prolonged metabolic abnormalities in reperfused canine myocardium.
BACKGROUND Prolonged metabolic abnormalities have been demonstrated previously in postischemic myocardium, including relative increases in glucose uptake and abnormal fatty acid kinetics. However, quantitative metabolic information is limited, and the time course of changes in MVO2 in postischemic myocardium is unknown. To address these issues, chronically instrumented dogs were studied seriall...
متن کاملBinding Protein in Ischemic and Reperfused Myocardium
In this study, fatty acid binding protein was used to protect an ischemic heart from reperfusion injury. Isolated rat heart was preperfused in the presence of 1.4 ,uM liposome-bound fatty acid binding protein for 15 minutes, followed by 30 minutes of ischemia and 30 minutes of reperfusion. Our results indicated better preservation of myocardial high-energy phosphate compounds (including ATP and...
متن کاملMyocardial clearance of technetium-99m-teboroxime in reperfused injured canine myocardium
BACKGROUND Recent technical developments using solid-state technology have enabled rapid image acquisition with single photon emission computed tomography (SPECT) and have led to a renewed interest in technetium-99m-teboroxime (Tc-99m-teboroxime) as a myocardial imaging agent. Tc-99m-teboroxime has demonstrated high myocardial extraction, linear myocardial uptake relative to flow even at high f...
متن کاملCorrelation between [5-3H]glucose and [U-14C]deoxyglucose as markers of glycolysis in reperfused myocardium.
Studies were conducted in extracorporeally perfused, intact, working pig hearts to determine whether, in heart muscle, trace-labeled deoxyglucose serves as an accurate marker of glycolytic flux in reperfusion after exposures to mild to moderate regional ischemia. In the main study, two groups of hearts were compared, as distinguished by levels of glucose in the whole-blood perfusate (euglycemic...
متن کاملGlucose metabolism in reperfused myocardium measured by [2-18F] 2-fluorodeoxyglucose and PET.
OBJECTIVE [2-18F] 2-fluorodeoxyglucose (FDG) is widely used to trace glucose metabolism for cardiac imaging with positron emission tomography. Because the transport and phosphorylation rates differ for glucose and FDG, a lumped constant (LC) is used to correct for these differences. The effects of ischemia and reperfusion on the LC in vivo are unknown. To determine the validity of FDG as a trac...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 1989
ISSN: 0735-1097
DOI: 10.1016/0735-1097(89)90621-9